Eurofins Discovery

Website: www.eurofinsdiscovery.com

Eurofins Discovery accelerates the critical drug discovery endeavor for our global clients through decades of experience and flexible solutions. We provide comprehensive services from assay-ready development to DiscoveryOne™ integrated programs; chemistry, in vitro safety and efficacy phenotypic assays, ADME-tox and pre-clinical pharmacology. Whether you require outsourcing needs or perform research in-house, Eurofins Discovery Services and Eurofins DiscoverX® product solutions empowers R&D through IND. 

Aragen

Website: https://www.aragen.com/

BirdoTech

Website: http://www.birdotech.com/

Fidabio

Website: https://fidabio.com/

NanoImaging Services

Website: https://www.nanoimagingservices.com/

Visualizing biomolecular structures through cryo-EM studies can provide insight into multiple stages of the drug development process, from target identification through manufacturing. As the industry leader in cryo-EM, with more cryo-EM scientists and TEM microscopes than any service provider in North America, NanoImaging Services is a CRO specializing in harnessing the power of cryo-EM to enable structure based drug design of a variety of targets including PROTAC and molecular glue based complexes.

Nanome.AI

Website: https://nanome.ai/

Nanome is changing how we understand, design, and interact with science. Nanome’s immersive virtual workspaces allow users to visualize, modify, and simulate chemical compounds, proteins, and nucleic acids to help improve the Drug Discovery process. 

Our virtual reality platform facilitates communication of structural data in drug discovery which has proved beneficial to pharmaceutical and biotech companies across the globe. This is especially helpful for organizations that are interested in improving their cross-site collaboration. 

OmicScouts

Website: https://www.omicscouts.com/en/

OmicScouts is a world-leading chemical proteomics company and supports drug discovery as a service for pharmaceutical and biotech companies: 

ProteomeScout – quantification of 6-11.000 proteins from treated and control samples;

TurnoverScout - longitudinal quantitative proteome turnover determination, supporting optimization of target modulation therapies (degraders, PROTACs, siRNA, RNAi); 

CysScout- cysteine reactive proteome profiling of covalent compounds, site identification and occupancy quantification; 

SideScout - label free, concentration-dependent target deconvolution at physiological temperature; 

TargetScout - affinity based target identification, target engagement, and target selectivity; 

SignallingScout - elucidating proteome -wide compound-induced signaling changes; 

KinomeScout – compoundbinding quantification on up to 310 human kinases under near physiological conditions;

Proteome Sciences

Website: https://www.proteomics.com/

Proteome Sciences is a Contract Research Organisation (CRO) specialising in the analysis of proteins detected by Mass Spectrometry.  We offer various Discovery and Targeted Services to characterise proteins and their associated post translational modifications. 

By using LC-MS2, LC-MS3, SysQuant® and TMTcalibratorTM methodologies on samples that originate from tissue to biological fluids, we can detect over 8,000 proteins per sample.  With our proprietary bioinformatics software, these can be trimmed down to some tens of proteins that are either up-, or down-regulated in either disease progression or drug treatment. 

Using our unique TMTpro isobaric mass tags, we can run up to 15 samples per single experiment thereby allowing relative protein quantification between samples.  By using a reference channel, multiple experiments can be performed sequentially, thereby allowing 30 to 100+ samples to be characterized in one project.   Sensitivity is equivalent to conventional ELISA in many cases.

In the clinical area, we offer single or multiplexed protein measurements on customer selected proteins either with or without a PTM.  Proteins selected can be either known previously, or more often detected above via our Discovery Services.  We can measure up to 100 multiplex proteins per sample in a GCLP accredited Targeted Mass Spectrometric assay using clinically relevant samples such as plasma and CSF. Again, sensitivity is equivalent to conventional ELISA in many cases.